主講人：黃勇教授 【佛羅裡達大學蓋恩斯維爾分校，機械與航天工程系教授】

時間：2019年2月27日上午10：30開始

地點：大學城校區工學二号館202會議室

Abstract: Maskless (including extrusion-, laser-, and inkjet-based) three-dimensional (3D) cell bioprinting is a revolutionary advance for printing arbitrary cellular patterns as well as creating heterogeneous living constructs. More importantly, bioprinting provides a promising solution to the problem of organ donor shortage by providing printed tissue/organ constructs for transplantation, resulting in what is known as organ printing. While there are various technological advances for bioprinting, cell-laden viscoelastic fluid printing and printing-induced cell injury still pose significant challenges to ensuring the scale-up of robust bioprinting. Using laser bioprinting (laser-induced forward transfer) and inkjet bioprinting as two jet-based model printing systems, we have been studying the bioink jettability and printability as well as printing-induced cell injury problems, aiming to achieve robotic bioprinting. In this talk, the perspective of ongoing bioprinting research and various bioprinting technologies are first introduced. Then the jettability and printability of cell-laden viscoelastic bioinks are discussed using the dimensionless Ohnesorge and elasto-capillary numbers to capture the influence of material properties along with the Weber number to capture the influence of printing conditions. Furthermore, the modeling of laser-induced cellular droplet formation and landing processes is presented, and the relationship between the mechanical loading information and post-transfer cell injury/viability is established using an apoptosis signaling pathway-based modeling approach. Finally, this talk shares some thoughts regarding bioprinting-related basic scientific challenges.

Biography:

Dr. Yong Huang is a professor of Mechanical and Aerospace Engineering, Biomedical Engineering, and Materials Science and Engineering at the University of Florida, Gainesville, Florida. His research interests are two-fold: 1) processing of biological and engineering materials for healthcare/energy applications, and 2) understanding of dynamic material behavior during manufacturing and process-induced damage or defect structures. His current research topics include three-dimensional (3D) printing of biological and engineering structures, precision engineering of medical implants and performance evaluation of machined implants, and fabrication of polymeric microspheres / microcapsules / hollow fiber membranes. He served as the Technical Program Chair for the 2010 American Society of Mechanical Engineers International Manufacturing Science and Engineering Conference (ASME MSEC 2010) and the 2012 International Symposium on Flexible Automation (ISFA 2012). He received various awards for his manufacturing research contributions including the ASME Blackall Machine Tool and Gage Award (2005), the Society of Manufacturing Engineers Outstanding Young Manufacturing Engineer Award (2006), the NSF CAREER Award (2008), and the ASME International Symposium on Flexible Automation Young Investigator Award (2008). He received his Ph.D. in Mechanical Engineering from the Georgia Institute of Technology in 2002 and is a Fellow of ASME.

個人簡介：黃勇教授，現任佛羅裡達大學蓋恩斯維爾分校機械與航天工程系、生物醫學工程系以及材料科學與工程系教授。主要從事生物與工程材料加工、工藝損傷與缺陷結構研究等領域的研究。目前，黃勇教授主要研究方向包括生物與工程結構3D打印、醫學植入體精密工程與機加工植入物性能評估，以及高聚物功能微球/微膠囊包裹體/孔洞纖維膜的制造。黃勇教授于2002年12月取得美國佐治亞理工學院機械工程博士學位，目前是美國機械工程師學會會士（ASME Fellow）。曾任美國機械工程師協會2010年國際制造科學與工程大會(ASME MSEC 2010)和2012年柔性自動化國際研讨會(ISFA 2012)技術委員會主席。黃博士在制造工程領域的貢獻為其獲得了多項獎項，包括ASME Blackall Machine Tool and Gage Award (2005，布來科爾機器工具與器具ASME年度最佳論文獎。注：ASME制造工程期刊每年僅選出一篇獲獎論文)，美國制造工程師學會“傑出青年制造工程師獎” （2006），美國國家科學基金會“基金會傑出青年教授獎”（2008）以及美國機械工程師協會柔性自動化國際研讨會“青年研究者獎”（2008）等多個獎項。